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Related studies have found that the prognosis is related to the nature of the individual tumor, that is, as we mentioned above, hot tumors tend to respond to immunotherapy, while cold tumors and immunosuppressed/excluded tumors do not respond or respond weakly to immunotherapy

[2] Gril B, et al

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When a random set of parameters is generated, we then examined the generated set of initial parameters and whether they are confined to a steady state of metabolic flux for 24 hours before the glucose administration using the experimentally measured molecule concentrations as the initial values